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Endogenous IFNλ in Viral Hepatitis Patients
- Source :
- Journal of Interferon & Cytokine Research. 34:552-556
- Publication Year :
- 2014
- Publisher :
- Mary Ann Liebert Inc, 2014.
-
Abstract
- Besides type I interferons (IFNs), type III IFNs, including IFNλ1 (interleukin-29 [IL-29]), possess potent antiviral activity. In patients infected with the hepatitis C virus (HCV), it has been demonstrated that viral clearance is associated with genetic variation near the IFNλ3 (IL-28B) gene. The rapid influx of research being conducted on this family of cytokines has led to several inconsistencies and controversies, including the possible correlation of serum cytokine levels with disease in chronic viral hepatitis patients. In a detailed study, well-characterized cohorts of patients with HBV and HCV were evaluated with 3 different immunoassays, and no differences in the levels of serum IFNλ were observed between patient groups, disease stages, or clinical parameters.
- Subjects :
- Adult
Male
Adolescent
Hepatitis C virus
Immunology
Endogeny
Disease
medicine.disease_cause
Cohort Studies
Interferon-gamma
Hepatitis B, Chronic
Virology
Genetic variation
Humans
Medicine
Gene
Aged
Aged, 80 and over
business.industry
Cell Biology
Hepatitis C
Hepatitis C, Chronic
Middle Aged
Hepatitis B
medicine.disease
Female
business
Viral hepatitis
Subjects
Details
- ISSN :
- 15577465 and 10799907
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Interferon & Cytokine Research
- Accession number :
- edsair.doi.dedup.....efe5d7fb4ef202a9a7b84bf2fc11a00d