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Length of hospitalization is associated with selected biomarkers (albumin and lymphocytes) and with co-morbidities: study on 4000 patients
- Source :
- Biomarker Research
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Background Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation between low blood levels of albumin, low lymphocytes, and length of stay. The secondary aim was to identify other co-morbidities associated with prolonged hospital stay. Methods Retrospective pilot study was conducted by analyzing anamnestic and biochemical data, related to 4038 patients admitted to ten wards of Hospital San Paolo (Milan), collected from July 1st 2012 to December 31st 2012. A statistical analysis was carried out using the Correlation method, Multivariate Analysis and Regression. Lymphocyte count and co-morbidities were evaluated in the whole cohort, albumin levels in 1437 patients. Results In the whole sample, low albumin levels and low lymphocyte counts were directly correlated to longer hospitalizations. The stratification of the results by department and diagnosis suggests that there is a higher correlation in certain subpopulations, and albumin shows a greater correlation with length of stay than lymphocytes. Also advanced age, high platelets, type of diagnosis, male gender and emergency admission led to longer hospitalizations. Conclusions A routine check of albumin, lymphocytes and a spectrum of significant variables can provide precious information which can eventually lead to a shorter hospital stay. Knowledge of the general health status of a patient and the possibility to estimate his/her length of hospital stay are essential information for Clinical Governance, and for the improvement of internal services of hospitals on a large scale.
- Subjects :
- 0301 basic medicine
Low albumin
medicine.medical_specialty
Multivariate analysis
Lymphocyte
Clinical Biochemistry
Length of hospitalization
Screening method
03 medical and health sciences
Internal medicine
Medicine
Case Series
Lymphocytes
Co-morbidities
Male gender
030109 nutrition & dietetics
business.industry
Albumin
Biochemistry (medical)
Surgery
medicine.anatomical_structure
Cohort
Length of stay
Molecular Medicine
Co morbidity
business
Subjects
Details
- ISSN :
- 20507771
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Biomarker Research
- Accession number :
- edsair.doi.dedup.....eff3f44cf47e0a28046468aacf3a6b05