Back to Search
Start Over
Synthesis and biological evaluation of new naphthoquinones derivatives
- Source :
- Current Organic Synthesis, Current Organic Synthesis, Bentham Science Publishers, 2020, ⟨10.2174/1570179417666200212111956⟩, Current Organic Synthesis, Bentham Science Publishers, 2020, 17 (3), pp.224-229. ⟨10.2174/1570179417666200212111956⟩, Current Organic Synthesis, 2020, 17 (3), pp.224-229. ⟨10.2174/1570179417666200212111956⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- New substituted 1,4-naphthoquinones have been prepared in good overall yields through the naphthol route. The cytotoxicity of these compounds was tested in vitro on MCF-7 breast tumor cells. The most active compound 14 displayed an IC50 of 15μM. Objective: To investigate the cytotoxicity of new naphthoquinones derivatives on MCF-7 cells. Methods: Synthesis of new naphtoquinones derivatives and in vitro evaluation of their cytotoxicity on MCF-7 cells (rezasurin cell-based assay). Results: Starting from Ethyl 4-hydroxy-6,7-dimethoxy-2-naphthoate, four naphthoquinones were prepared and exhibited substantial cytotoxicity against MCF-7 cells. Conclusion: Preliminary studies of the structure-activity relationship have shown the influence of the structural parameters and, in particular, the nature of the naphthoquinone side chain.
- Subjects :
- [SDV]Life Sciences [q-bio]
Cytotoxicity
Cell
Antineoplastic Agents
[SDV.CAN]Life Sciences [q-bio]/Cancer
010402 general chemistry
01 natural sciences
Biochemistry
Structure-Activity Relationship
chemistry.chemical_compound
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Side chain
medicine
Humans
Human breast cancer cell line MCF-7
IC50
ComputingMilieux_MISCELLANEOUS
Cell Proliferation
Biological evaluation
Antitumor agents
Molecular Structure
010405 organic chemistry
Organic Chemistry
Quinones
Combinatorial chemistry
Naphthoquinone
In vitro
3. Good health
0104 chemical sciences
medicine.anatomical_structure
chemistry
Active compound
MCF-7 Cells
Drug Screening Assays, Antitumor
Medicinal Chemistry
Naphthoquinones
Subjects
Details
- Language :
- English
- ISSN :
- 15701794
- Database :
- OpenAIRE
- Journal :
- Current Organic Synthesis, Current Organic Synthesis, Bentham Science Publishers, 2020, ⟨10.2174/1570179417666200212111956⟩, Current Organic Synthesis, Bentham Science Publishers, 2020, 17 (3), pp.224-229. ⟨10.2174/1570179417666200212111956⟩, Current Organic Synthesis, 2020, 17 (3), pp.224-229. ⟨10.2174/1570179417666200212111956⟩
- Accession number :
- edsair.doi.dedup.....f0033707a27e4fb13b798b32ca131b6c