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PINK1/Parkin mitophagy and neurodegeneration—what do we really know in vivo?
- Source :
- Current Opinion in Genetics & Development. 44:47-53
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Mitochondria are essential organelles that provide cellular energy and buffer cytoplasmic calcium. At the same time they produce damaging reactive oxygen species and sequester pro-apoptotic factors. Hence, eukaryotes have evolved exquisite homeostatic processes that maintain mitochondrial integrity, or ultimately remove damaged organelles. This subject has garnered intense interest recently following the discovery that two Parkinson's disease genes, PINK1 and parkin, regulate mitochondrial degradation (mitophagy). The molecular details of PINK1/Parkin-induced mitophagy are emerging but much of our insight derives from work using cultured cells and potent mitochondrial toxins, raising questions about the physiological significance of these findings. Here we review the evidence supporting PINK1/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.
- Subjects :
- 0301 basic medicine
Ubiquitin-Protein Ligases
Mitochondrial Degradation
PINK1
Mitochondrion
Biology
Parkin
03 medical and health sciences
In vivo
Mitophagy
medicine
Genetics
Humans
chemistry.chemical_classification
Reactive oxygen species
Neurodegeneration
Parkinson Disease
medicine.disease
nervous system diseases
Cell biology
Mitochondria
030104 developmental biology
chemistry
Nerve Degeneration
Calcium
Reactive Oxygen Species
Protein Kinases
Developmental Biology
Subjects
Details
- ISSN :
- 0959437X
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Genetics & Development
- Accession number :
- edsair.doi.dedup.....f00762257ff72469a169573b0f06f444
- Full Text :
- https://doi.org/10.1016/j.gde.2017.01.016