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Neutrophilic airway inflammation is a main feature of induced sputum in nonatopic asthmatic children
- Source :
- Allergy. 64(11)
- Publication Year :
- 2009
-
Abstract
- Background: Asthma phenotypes are well described among children. However, there are few studies comparing airway inflammation in different clinical presentations of pediatric asthma. We tested the hypothesis that nonatopic asthma is associated with a predominant noneosinophilic inflammation in the airways, as assessed by induced sputum. The objective of this study was to evaluate the cytological characteristics of induced sputum (IS) in atopic (AA), nonatopic asthmatics (NAA) and nonatopic nonasthmatic children (NANA). Methods: Of 90 selected children, 77 met eligibility criteria for performing IS and were classified as: AA, n = 28, NAA, n = 29 and NANA, n = 19. Subjects answered to a set of ISAAC-based questions and were skin-tested for common aeroallergens. A defined series of exclusion criteria was applied. Results: Induced sputum was obtained from 54 (70.1%) subjects (21 AA, 20 NAA and 13 NANA). Demographic data and mean FEV1 were similar in the three groups. The proportion of eosinophils [median, inter quartile range (IQR)] was significantly higher in the sputum of AA [(6.0.)12)] compared with NAAs [0 (2)] and NANAs [0 (1)], P 3%) was also significantly higher in AA (71.4%) when compared with NAA (28.6%); none of the NANA had sputum eosinophilia. Nonatopic asthmatic children had significantly higher proportions and absolute number of neutrophils than AA and controls. Conclusions: The results suggest that nonatopic children present IS with a cell pattern that is predominantly neutrophilic while eosinophilia is the hallmark of airway inflammation in the majority of atopic wheezing children not treated with inhaled steroids.
- Subjects :
- Hypersensitivity, Immediate
Male
Adolescent
Neutrophils
Immunology
Interquartile range
Immunopathology
medicine
Immunology and Allergy
Eosinophilia
Humans
Respiratory system
Child
Asthma
Inflammation
business.industry
Respiratory disease
Sputum
medicine.disease
respiratory tract diseases
medicine.anatomical_structure
Case-Control Studies
Female
medicine.symptom
business
Respiratory tract
Subjects
Details
- ISSN :
- 13989995
- Volume :
- 64
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Allergy
- Accession number :
- edsair.doi.dedup.....f00c353ccb6404610fcaf7c8647b6115