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Ceria-Zirconia Antioxidant Nanoparticles Attenuate Hypoxia-Induced Acute Kidney Injury by Restoring Autophagy Flux and Alleviating Mitochondrial Damage
- Source :
- Journal of Biomedical Nanotechnology. 16:1144-1159
- Publication Year :
- 2020
- Publisher :
- American Scientific Publishers, 2020.
-
Abstract
- Oxidative stress is one of the principal causes of hypoxia-induced kidney injury. The ceria nanoparticle (CNP) is known to exhibit free radical scavenger and catalytic activities. When zirconia is attached to CNPs (CZNPs), the ceria atom tends to remain in a Ce3+ form and its efficacy as a free radical scavenger thus increases. We determined the effectiveness of CNP and CZNP antioxidant activities against hypoxia-induced acute kidney injury (AKI) and observed that these nanoparticles suppress the apoptosis of hypoxic HK-2 cells by restoring autophagy flux and alleviating mitochondrial damage. In vivo experiments revealed that CZNPs effectively attenuate hypoxia-induced AKI by preserving renal structures and glomerulus function. These nanoparticles can successfully diffuse into HK-2 cells and effectively counteract reactive oxygen species (ROS) to block hypoxia-induced AKI. This suggests that these particles represent a novel approach to controlling this condition.
- Subjects :
- Antioxidant
medicine.medical_treatment
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Apoptosis
Bioengineering
Mitochondrion
medicine.disease_cause
Antioxidants
Autophagy
medicine
Humans
General Materials Science
Hypoxia
chemistry.chemical_classification
Reactive oxygen species
Acute kidney injury
Acute Kidney Injury
Free radical scavenger
medicine.disease
Oxidative Stress
chemistry
Biophysics
Nanoparticles
Zirconium
Reactive Oxygen Species
Oxidative stress
Subjects
Details
- ISSN :
- 15507033
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Nanotechnology
- Accession number :
- edsair.doi.dedup.....f00c5ef3732110d2008886baeafab3f8
- Full Text :
- https://doi.org/10.1166/jbn.2020.2948