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Ceria-Zirconia Antioxidant Nanoparticles Attenuate Hypoxia-Induced Acute Kidney Injury by Restoring Autophagy Flux and Alleviating Mitochondrial Damage

Authors :
Chang Gyo Park
Hoi Young Lee
Won-Min Hwang
Jaeku Kang
Sung-Ro Yun
Seong-Lan Yu
Jong Hun An
Moon Hyang Park
Kuk Ro Yoon
Hwan-Woo Park
Sang-Eun Hong
Se-Hee Yoon
Dong Chul Lee
Source :
Journal of Biomedical Nanotechnology. 16:1144-1159
Publication Year :
2020
Publisher :
American Scientific Publishers, 2020.

Abstract

Oxidative stress is one of the principal causes of hypoxia-induced kidney injury. The ceria nanoparticle (CNP) is known to exhibit free radical scavenger and catalytic activities. When zirconia is attached to CNPs (CZNPs), the ceria atom tends to remain in a Ce3+ form and its efficacy as a free radical scavenger thus increases. We determined the effectiveness of CNP and CZNP antioxidant activities against hypoxia-induced acute kidney injury (AKI) and observed that these nanoparticles suppress the apoptosis of hypoxic HK-2 cells by restoring autophagy flux and alleviating mitochondrial damage. In vivo experiments revealed that CZNPs effectively attenuate hypoxia-induced AKI by preserving renal structures and glomerulus function. These nanoparticles can successfully diffuse into HK-2 cells and effectively counteract reactive oxygen species (ROS) to block hypoxia-induced AKI. This suggests that these particles represent a novel approach to controlling this condition.

Details

ISSN :
15507033
Volume :
16
Database :
OpenAIRE
Journal :
Journal of Biomedical Nanotechnology
Accession number :
edsair.doi.dedup.....f00c5ef3732110d2008886baeafab3f8
Full Text :
https://doi.org/10.1166/jbn.2020.2948