Back to Search
Start Over
Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans
- Source :
- Marine Drugs; Volume 15; Issue 6; Pages: 177, Marine Drugs
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4–7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.
- Subjects :
- Circular dichroism
Magnetic Resonance Spectroscopy
Stereochemistry
Pharmaceutical Science
010402 general chemistry
DFT
01 natural sciences
Article
sponge
crellasterone
Crella incrustans
Crella
Drug Discovery
Animals
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
biology
010405 organic chemistry
steroid
marine natural products
Chromophore
biology.organism_classification
Porifera
0104 chemical sciences
Sponge
Density functional theory
Norsteroids
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Database :
- OpenAIRE
- Journal :
- Marine Drugs; Volume 15; Issue 6; Pages: 177
- Accession number :
- edsair.doi.dedup.....f0257a890c23bee4875e7e1a6eb2a3ba
- Full Text :
- https://doi.org/10.3390/md15060177