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Synthesis of spirocyclic scaffolds using hypervalent iodine reagents

Authors :
Samata E. Shetgaonkar
Fateh V. Singh
Saeesh R. Mangaonkar
Priyanka B. Kole
Source :
Beilstein Journal of Organic Chemistry, Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1778-1805 (2018)
Publication Year :
2018
Publisher :
Beilstein Institut, 2018.

Abstract

Hypervalent iodine reagents have been developed as highly valuable reagents in synthetic organic chemistry during the past few decades. These reagents have been identified as key replacements of various toxic heavy metals in organic synthesis. Various synthetically and biologically important scaffolds have been developed using hypervalent iodine reagents either in stoichiometric or catalytic amounts. In addition, hypervalent iodine reagents have been employed for the synthesis of spirocyclic scaffolds via dearomatization processes. In this review, various approaches for the synthesis of spirocyclic scaffolds using hypervalent iodine reagents are covered including their stereoselective synthesis. Additionally, the applications of these reagents in natural product synthesis are also covered.

Details

ISSN :
18605397
Volume :
14
Database :
OpenAIRE
Journal :
Beilstein Journal of Organic Chemistry
Accession number :
edsair.doi.dedup.....f0384ee10f2e69526061cc591decd1a3
Full Text :
https://doi.org/10.3762/bjoc.14.152