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Human T-cell lymphotropic virus type I associated adult T-cell leukaemia/lymphoma in Taiwan Chinese
- Source :
- British Journal of Haematology. 79:156-161
- Publication Year :
- 1991
- Publisher :
- Wiley, 1991.
-
Abstract
- Summary Twenty-five Chinese patients with human T-cell lymphotropic virus type I (HTLV-I) associated adult T-cell leukaemia/lymphoma (ATLL) were identified in Taiwan. No patients had been outside Taiwan and none were descendants of Japanese heritage. Their ages ranged from 28 to 71 years. There were 17 men and eight women. Main clinical and laboratory features at presentation were lymphadenopathy (16), skin lesions (11), hepatosplenomegaly (11), pulmonary lesions (11), hypercalcaemia (10) and bone marrow infiltration (14). Peripheral blood was characterized by leucocytosis with presence of pleomorphic abnormal lymphocytes but rare anaemia or thrombocytopenia. The clinical subtypes were acute in 15, chronic in three, smouldering in one, and lymphoma type in six. The immunopheno-types of the ATLL cells were characterized by the expression of CD2+, CD4+, CD7-, CD8- and CD25+. The overall prognosis was poor with a median survival of 5 months. The acute form had a significantly shorter survival (2 months) than lymphoma type (13 months). Susceptibility to various infections was common. Pulmonary complications accounted for 73% of the causes of death. The clinicopathologic features of ATLL in Taiwan are indistinguishable from those in HTLV-I endemic areas. The present series adds to the knowledge of the worldwide pattern of the disease.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Hypercalcaemia
T cell
Taiwan
Hepatosplenomegaly
Virus
Immunophenotyping
Bone Marrow
hemic and lymphatic diseases
medicine
Humans
Leukemia-Lymphoma, Adult T-Cell
IL-2 receptor
Aged
business.industry
Hematology
Middle Aged
medicine.disease
Lymphoma
medicine.anatomical_structure
Female
medicine.symptom
business
Abnormal Lymphocyte
CD8
Subjects
Details
- ISSN :
- 13652141 and 00071048
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....f04778bbcacf9468d88863a70ed57b39
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1991.tb04516.x