Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial

Authors :: Kazuhiro Katayama
Izumi Hamada
Atsushi Hosui
Minoru Itou
Tetsuo Takehara
Yasushi Matsuzaki
Katsunori Miyoshi
Hiroko Kodama
Keiko Hosho
Yoriyuki Takamori
Yoshiyuki Sakai
Yasuhiro Takikawa
Yoko Miyoshi
Tomomi Tsuru
Toshifumi Ito
Shinobu Ida
Kojiro Michitaka
Eishin Ogawa
Source :: Biological Trace Element Research
Publication Year :: 2019
Publisher :: Springer US, 2019.
Abstract: The essential trace element zinc maintains liver functions. Liver diseases can alter overall zinc concentrations, and hypozincemia is associated with various hepatic pathologies. Modulating systemic zinc through dietary supplementation is potentially useful for liver diseases. We evaluated the usefulness of zinc (NPC-02; acetate formulation) supplementation. We conducted two NPC-02 studies on zinc-deficient patients (serum zinc

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