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A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A
- Source :
- Neurology. 61(7)
- Publication Year :
- 2003
-
Abstract
- Objective: Botulinum toxin type A (BTXA) is used to treat neurologic disorders associated with increased muscle tone. Its use is often associated with pain relief. Methods: A possible direct analgesic effect of BTXA on C and Aδ fibers was studied on 16 healthy volunteers receiving 30 U BTXA into one forearm and pure saline into the other. To exclude the secondary effect due to muscular tone reduction, BTXA was injected intradermally. Thermal sensory testing of heat pain (threshold and tolerance) and neuroselective current sensory testing of current pain threshold/tolerance were performed at baseline and 3, 14, and 28 days after treatment. Thereafter, on day 28, capsaicin was administered simultaneously into both forearms to evaluate a possible peripheral effect and central effect on pain processing and on the axon reflex flare. Results: The authors observed no significant difference in any of the perception outcome measures between BTXA and placebo pretreated areas. Flare areas as a result of the release of neuropeptides after capsaicin application showed no differences. Conclusions: The results suggest that pain reduction after BTXA treatment is mediated through its effect on muscle tone rather than a direct analgesic effect.
- Subjects :
- Adult
Male
Pain Threshold
Randomization
Hot Temperature
Injections, Intradermal
medicine.medical_treatment
Analgesic
Placebo-controlled study
Pain
Placebo
Nerve Fibers, Myelinated
Placebos
Muscle tone
Forearm
Double-Blind Method
Reference Values
Threshold of pain
medicine
Humans
Botulinum Toxins, Type A
Saline
Pain Measurement
Skin
Analgesics
Nerve Fibers, Unmyelinated
business.industry
Electric Stimulation
medicine.anatomical_structure
Treatment Outcome
Hyperalgesia
Anesthesia
Female
Neurology (clinical)
Capsaicin
business
Subjects
Details
- ISSN :
- 1526632X
- Volume :
- 61
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....f05a256dbe113daa2a9e0b296103c379