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Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex
- Source :
- Neuropharmacology. 44:40-48
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.
- Subjects :
- Male
Long-Term Potentiation
Hippocampus
Galanin
Cholinergic Agonists
In Vitro Techniques
Spatial memory
Mice
Cellular and Molecular Neuroscience
Visual memory
Memory
Perirhinal cortex
medicine
Animals
Mice, Knockout
Pharmacology
Neuronal Plasticity
Long-term memory
Long-Term Synaptic Depression
digestive, oral, and skin physiology
Retention, Psychology
Long-term potentiation
medicine.anatomical_structure
Pattern Recognition, Visual
Space Perception
Synaptic plasticity
Parahippocampal Gyrus
Carbachol
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 00283908
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Neuropharmacology
- Accession number :
- edsair.doi.dedup.....f0623d3ef64de098c56c20b55d06a7c6