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Unlike AML1, CBFβ gene is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes
- Source :
- Blood. 99:3848-3850
- Publication Year :
- 2002
- Publisher :
- American Society of Hematology, 2002.
-
Abstract
- The core-binding factor (CBF) complex is a heterodimeric transcription factor composed of 2 subunits, CBFalpha and CBFbeta, that play a major role in hematopoiesis. Both members of the CBF complex are frequently altered in acute myeloid leukemia (AML) by translocation, most commonly t(8;21), t(12;21), and t(3;21) for CBFalpha, located in 21q22, and inv(16)(p13;q22) for CBFbeta, located on 16q22. Recently, a new mechanism of alteration of CBFalpha, by point mutation, has been reported in myeloid malignancies, particularly in M0 AML. In the present study, we found no point mutation of the CBFbeta gene in 30 myelodysplastic syndromes and 100 AMLs, suggesting a limited role, if any, of CBFbeta point mutations in those disorders.
- Subjects :
- Myeloid
Immunology
Chromosomal translocation
Biology
Biochemistry
Proto-Oncogene Proteins
hemic and lymphatic diseases
medicine
Humans
Point Mutation
Polymorphism, Single-Stranded Conformational
Genetics
Regulation of gene expression
Myelodysplastic syndromes
Point mutation
Myeloid leukemia
Cell Biology
Hematology
medicine.disease
DNA-Binding Proteins
Haematopoiesis
Leukemia
medicine.anatomical_structure
Gene Expression Regulation
Transcription Factor AP-2
Leukemia, Myeloid
Myelodysplastic Syndromes
Acute Disease
Core Binding Factor Alpha 2 Subunit
Cancer research
Transcription Factors
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....f07ab192651e11da32a23fbedad7f735
- Full Text :
- https://doi.org/10.1182/blood.v99.10.3848