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Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice

Authors :
Mirko Schlawinsky
Thomas Heinemann
Hans-Dieter Volk
Richard S. Blumberg
M. Winter
Nalan Utku
Patricia A. Fraser
Edward E. S. Nieuwenhuis
C. G. Bulwin
Pediatrics
Source :
Clinical & Experimental Immunology, 144, 142-151. Wiley-Blackwell Publishing Ltd
Publication Year :
2006
Publisher :
Blackwell Science Inc, 2006.

Abstract

Summary TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-α receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.

Details

Language :
English
ISSN :
00099104
Database :
OpenAIRE
Journal :
Clinical & Experimental Immunology, 144, 142-151. Wiley-Blackwell Publishing Ltd
Accession number :
edsair.doi.dedup.....f08177375eaf2273708ffc332bd587d3