Back to Search
Start Over
Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice
- Source :
- Clinical & Experimental Immunology, 144, 142-151. Wiley-Blackwell Publishing Ltd
- Publication Year :
- 2006
- Publisher :
- Blackwell Science Inc, 2006.
-
Abstract
- Summary TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-α receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.
- Subjects :
- musculoskeletal diseases
Male
Vacuolar Proton-Translocating ATPases
Knee Joint
medicine.drug_class
T cell
T-Lymphocytes
Immunology
Monoclonal antibody
Receptors, Tumor Necrosis Factor
Arthritis, Rheumatoid
Mice
Antigen
Synovial Fluid
medicine
Immunology and Allergy
Animals
Humans
Receptor
B cell
B-Lymphocytes
Mice, Inbred BALB C
biology
business.industry
Tumor Necrosis Factor-alpha
Antibodies, Monoclonal
medicine.disease
Arthritis, Experimental
Up-Regulation
medicine.anatomical_structure
Mice, Inbred DBA
Rheumatoid arthritis
Immunoglobulin G
biology.protein
Animal Studies
Tumor necrosis factor alpha
Female
Immunotherapy
Antibody
business
Immunologic Memory
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Database :
- OpenAIRE
- Journal :
- Clinical & Experimental Immunology, 144, 142-151. Wiley-Blackwell Publishing Ltd
- Accession number :
- edsair.doi.dedup.....f08177375eaf2273708ffc332bd587d3