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WRNIP1: A new guardian of genome integrity at stalled replication forks
- Publication Year :
- 2016
- Publisher :
- Taylor & Francis, 2016.
-
Abstract
- Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.
- Subjects :
- 0301 basic medicine
Genome instability
Genetics
Cancer Research
Replication stress
WERNER HELICASE-INTERACTING PROTEIN 1
Genome integrity
RAD51
Biology
Replication (computing)
03 medical and health sciences
enzymes and coenzymes (carbohydrates)
030104 developmental biology
WRNIP1
Recombinase
Molecular Medicine
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Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f08367e92649e5d01835afa20cff45f8