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Incidence of Type 2 Diabetes in Patients With Chronic Hepatitis C Receiving Interferon-Based Therapy
- Source :
- Diabetes Care
- Publication Year :
- 2020
- Publisher :
- American Diabetes Association, 2020.
-
Abstract
- Type 2 diabetes (T2D) has been associated with hepatitis C virus (HCV) infection as an independent risk factor. The increased insulin resistance induced by the HCV core protein or the treatment with interferon-based therapy (IBT) may have a role (1). It is generally agreed that IBT for patients with chronic hepatitis C (CHC) may trigger short-term insulin resistance. However, the long-term risk of developing T2D for CHC patients with IBT remains unclear. Studies suggested that if viral clearance is achieved after IBT, the risk of T2D might be reduced by two-thirds in CHC patients (2,3). An Italian study argued that a lower insulin resistance at baseline may be the reason for reduced risk of T2D (4). We therefore conducted a retrospective cohort study, using insurance claims data of Taiwan, to examine 1 ) whether CHC patients are at an elevated risk of developing T2D and 2 ) whether CHC patients receiving IBT are at a reduced risk of T2D, not only through viral clearance but also through possible alterations of glucose metabolism. The health insurance of Taiwan is a universal insurance system with 99% of all 23 million residents covered. We used a subset of claims data of 1 million beneficiaries randomly selected from all residents to …
- Subjects :
- Advanced and Specialized Nursing
medicine.medical_specialty
business.industry
Endocrinology, Diabetes and Metabolism
Hepatitis C virus
Incidence (epidemiology)
e-Letters: Observations
030209 endocrinology & metabolism
Retrospective cohort study
Type 2 diabetes
medicine.disease_cause
medicine.disease
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Interferon
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
030212 general & internal medicine
Risk factor
business
medicine.drug
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....f0894ba2993956a5e9ba9ae9470e33a7