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Heat Stress-Associated Growth Retardation in the First 1000 Days Is Mitigated by Preconception Nutritional Supplementation
- Source :
- Curr Dev Nutr
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- OBJECTIVES: Understanding the interactions between nutrition and climate-driven health outcomes is increasingly necessary. Employing data from the Women First trial conducted in Thatta, Pakistan, we examined the interactions between maternal nutritional deficits and heat stress (HS) on birth outcomes. METHODS: Women of child-bearing age either consumed a small quantity lipid-based nutrition supplement (sqLNS) prior to conception (Arm 1), from 12 wk of gestation until delivery (Arm 2); or were not supplemented with sqLNS (Arm 3). At the Pakistan site, samples sizes with birth outcomes obtained within 48 h of delivery for Arms 1, 2 and 3 were 157,150 and 138, respectively. Daily maximal air temperatures were used to were compute the average daily maximal temperatures (T(max)) for each infant over four 90-day windows representing each trimester of gestation and 3 mo preconception. The number of days in each period when the T(max) was > 39°C was computed to assess ‘heat stress days’. RESULTS: Linear regression models assessing the associations between heat exposure and outcome variables (gestational age adjusted Z-scores of birth length (LGAZ), birth weight (WGAZ) and head circumference (HCGAZ) revealed a striking negative association of both ambient temperature and HS days in the first trimester on birth length (LGAZ) and head circumference (HCGAZ) (p
- Subjects :
- Pregnancy
Nutrition and Dietetics
Nutritional Supplementation
Growth retardation
business.industry
Birth weight
Heat Stress Disorders
Climate/Environment, Agriculture and Food Supply
Medicine (miscellaneous)
Gestational age
Health outcomes
medicine.disease
Heat stress
Environmental health
Medicine
business
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Curr Dev Nutr
- Accession number :
- edsair.doi.dedup.....f09867fc12546a3ea273726ea7a9c6e4