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Correction to: The French glioblastoma biobank (FGB): a national clinicobiological database

Authors :
Jean-Michel Lemée
Pierre Dubus
Bijan Ghaleh
Chiara Villa
Gwenaelle Soulard
Philippe Menei
Anna Luisa Di Stefano
Odile BLANCHET
Pascale Fabbro-Peray
Karine Lacut
Source :
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-2 (2020), Journal of Translational Medicine
Publication Year :
2020
Publisher :
Springer Science and Business Media LLC, 2020.

Abstract

Background Glioblastomas (GB) are the most common and lethal primary brain tumors. Significant progress has been made toward identifying potential risk factors for GB and diagnostic and prognostic biomarkers. However, the current standard of care for newly diagnosed GB, the Stupp protocol, has remained unchanged for over a decade. Large-scale translational programs based on a large clinicobiological database are required to improve our understanding of GB biology, potentially facilitating the development of personalized and specifically targeted therapies. With this goal in mind, a well-annotated clinicobiological database housing data and samples from GB patients has been set up in France: the French GB biobank (FGB). Methods The biobank contains data and samples from adult GB patients from 24 centers in France providing written informed consent. Clinical and biomaterial data are stored in anonymized certified electronic case report forms. Biological samples (including frozen and formalin-fixed paraffin-embedded tumor tissues, blood samples, and hair) are conserved in certified biological resource centers or tumor tissue banks at each participating center. Results Clinical data and biological materials have been collected for 1087 GB patients. A complete set of samples (tumor, blood and hair) is available for 66%, and at least one frozen tumor sample is available for 88% of the GB patients. Conclusions This large biobank is unique in Europe and can support the large-scale translational projects required to improve GB care. Additional biological materials, such as peritumoral brain zone and fecal samples, will be collected in the future, to respond to research needs.

Details

ISSN :
14795876
Volume :
18
Database :
OpenAIRE
Journal :
Journal of Translational Medicine
Accession number :
edsair.doi.dedup.....f0a9d12c87c65836b91ec07eadad5ccc
Full Text :
https://doi.org/10.1186/s12967-020-02345-5