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Nocardia farcinica Brain Abscess in a Multiple Myeloma Patient Treated with Proteasome Inhibitor: A Case Report and Review of the Literature
- Source :
- Brain Sciences, Brain Sciences, Vol 11, Iss 1204, p 1204 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Nocardia brain abscess is relatively rare, accounting for about 1–2% of all brain abscesses, and its mortality rate is three times higher than of other types of bacterial brain abscesses; thus, early diagnosis and treatment are essential. Nocardia brain abscess generally occurs in immunodeficient patients. We report a case of Nocardia farcinica brain abscess in a multiple myeloma patient treated with proteasome inhibitor (bortezomib and ixazomib), cyclophosphamide, and corticosteroid. The patient was treated with ceftriaxone and trimethoprim-sulfamethoxazole, together with drainage of the brain abscess. Regular brain MRI follow-ups showed that intracranial lesions were gradually absorbed and improved.
- Subjects :
- Pathology
medicine.medical_specialty
Cyclophosphamide
Nocardia farcinica
Neurosciences. Biological psychiatry. Neuropsychiatry
Case Report
Ixazomib
chemistry.chemical_compound
medicine
Brain abscess
Multiple myeloma
biology
Bortezomib
business.industry
proteasome inhibitor
General Neuroscience
Nocardia
medicine.disease
biology.organism_classification
bacterial infections and mycoses
multiple myeloma
brain abscess
chemistry
Proteasome inhibitor
business
RC321-571
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20763425
- Volume :
- 11
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Brain Sciences
- Accession number :
- edsair.doi.dedup.....f0be1fcada012290f9b7802ede3f347f