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Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma
- Source :
- General Thoracic and Cardiovascular Surgery. 62:678-684
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The role of cell cycle inhibitors in tumorigenesis has been proven in various neoplasms; however, their roles in thymic tumors are still unclear. We examined the expression of cell cycle inhibitors such as those of the Cip/Kip family (p21, p27, and p57) and the INK-4/ARF family (p16 and p14) in thymoma and thymic carcinoma. Samples from 41 thymoma and 14 thymic carcinoma patients, and 34 normal thymic tissue samples were prepared for the study. Immunohistochemical analysis using antibodies to p21, p27, p57, p16, and p14 was carried out, and the positivity for these inhibitors in each group was estimated in terms of their subcellular location and percentage of cells showing positive staining. Nuclear p27 showed a stepwise decrease (p
- Subjects :
- Adult
Cyclin-Dependent Kinase Inhibitor p21
Male
Pulmonary and Respiratory Medicine
Thymoma
medicine.disease_cause
Malignancy
Biomarkers, Tumor
Humans
Medicine
Thymic carcinoma
Aged
Cyclin-Dependent Kinase Inhibitor Proteins
Neoplasm Staging
Aged, 80 and over
business.industry
Thymus Neoplasms
General Medicine
Middle Aged
Cell cycle
medicine.disease
Neoplasm Proteins
Thymic Tissue
Cytoplasm
Cancer research
Immunohistochemistry
Female
Surgery
Cardiology and Cardiovascular Medicine
business
Carcinogenesis
Cyclin-Dependent Kinase Inhibitor p27
Subjects
Details
- ISSN :
- 18636713 and 18636705
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- General Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....f0bf07d1c436c068a33165712e0e2f29