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Favorable early vessel healing after everolimus-eluting stent implantation: 3-, 6-, and 12-month follow-up of optical coherence tomography
- Source :
- Journal of Cardiology. 72:193-199
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background Although a prospective randomized control study revealed that 3-month dual anti-platelet therapy (DAPT) is safe and does not compromise the efficacy of everolimus-eluting stent (EES) in selected patients, detailed vessel healing at early phase after EES implantation has yet to be investigated in Japanese patients. Methods and results A total of 27 lesions in 19 patients treated with EES were serially evaluated by using optical coherence tomography (OCT) at 3, 6, and 12 months after stent implantation. In addition to standard quantitative OCT parameters, the percentage of stents with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (63 ± 17 μm; 83 ± 30 μm; and 111 ± 44 μm, respectively; p = 0.006) and small decrease in average lumen area (6.80 ± 2.57 mm2, 6.62 ± 2.58 mm2, 6.33 ± 2.58 mm2, p = 0.038) from the 3- to the 12-month follow-up. The incidences of uncovered and malapposed struts were low at 3 months and did not significantly change at 6 months and 12 months (3.01 ± 4.43; 2.45 ± 3.75; and 1.47 ± 3.16, p = 0.143, and 0.75 ± 0.65; 0.63 ± 0.73; and 0.58 ± 1.42, p = 0.162, respectively). Also, frequency of struts with PLIA was already low at three months and significantly decreased during the follow-up (6.4 ± 6.5; 4.6 ± 5.4; and 2.3 ± 3.3, respectively; p = 0.001). Conclusion Favorable vessel healing was achieved at 3 months after EES implantation without neointimal hyperplasia which was persistently suppressed up to 12 months.
- Subjects :
- Male
Neointima
medicine.medical_specialty
Everolimus eluting stent
medicine.medical_treatment
Lumen (anatomy)
030204 cardiovascular system & hematology
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Optical coherence tomography
Internal medicine
medicine
Humans
Everolimus
Postoperative Period
Prospective Studies
030212 general & internal medicine
Aged
Randomized Controlled Trials as Topic
Heart Valve Prosthesis Implantation
Neointimal hyperplasia
Wound Healing
Hyperplasia
medicine.diagnostic_test
business.industry
Stent
Drug-Eluting Stents
Middle Aged
medicine.disease
Coronary Vessels
Treatment Outcome
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Early phase
Tomography, Optical Coherence
Follow-Up Studies
Month follow up
Subjects
Details
- ISSN :
- 09145087
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....f0f8b30af1a844baa2ff9acffd775f3c