Back to Search
Start Over
Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder
- Source :
- Multiple Sclerosis and Related Disorders
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2, which affects the lung and other organs. After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with increased mortality. Immunosuppressed patients may have higher risk of adverse outcomes; hence, there is an urgent need to evaluate the immune response and clinical outcomes of SARS-CoV-2 infection in these patients. Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection.
- Subjects :
- Multiple Sclerosis
coronaviruses
Clinical Neurology
Disease
Neuromyelitis Optica Spectrum Disorder (NMOSD)
medicine.disease_cause
Article
03 medical and health sciences
0302 clinical medicine
Medicine
Humans
Immunologic Factors
030212 general & internal medicine
Coronavirus
Autoantibodies
Aquaporin 4
B-Lymphocytes
Neuromyelitis optica
SARS-CoV-2
business.industry
pandemic
Multiple sclerosis
Neuromyelitis Optica
COVID-19
General Medicine
Middle Aged
medicine.disease
Pneumonia
Neurology
Immunology
Rituximab
Female
Neurology (clinical)
business
Cytokine storm
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 22110348
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis and Related Disorders
- Accession number :
- edsair.doi.dedup.....f10685b125d087f2230704d584724827
- Full Text :
- https://doi.org/10.1016/j.msard.2020.102199