Back to Search
Start Over
Neuroprotection Mechanisms in Cerebral Hypothermia (Review)
- Source :
- Obŝaâ Reanimatologiâ, Vol 15, Iss 6, Pp 94-114 (2019)
- Publication Year :
- 2019
- Publisher :
- Russian Academy of Medical Sciences, 2019.
-
Abstract
- The review focuses on the neuroprotective mechanisms of therapeutic hypothermia from the standpoint of metabolic depression and genomic reprogramming of neurons that develop when brain temperature decreases.The concept of hypothermic pre-conditioning based on the development of typical nonspecific reactions for the formation of the cytoprotective phenotype of neurons due to potentially dangerous stimuli, such as ischemia, reperfusion, and hypothermia, was used to explain the effects of low temperatures. The data confirming the role of therapeutic cerebral hypothermia as a technique of selective brain exposure to mild cold for the neuroprotection and correction of temperature balance disorders are shown.The approach to therapeutic hypothermia as a hypothermic pre-conditioning allows to significantly expand the scope of its use in various procedural variants.
- Subjects :
- business.industry
RC86-88.9
brain
Ischemia
Balance disorders
Medical emergencies. Critical care. Intensive care. First aid
therapeutic hypothermia
030204 cardiovascular system & hematology
Hypothermia
Critical Care and Intensive Care Medicine
medicine.disease
pre-conditioning
Neuroprotection
thermal balance
03 medical and health sciences
0302 clinical medicine
Pre conditioning
Medicine
medicine.symptom
business
Thermal balance
Reprogramming
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- Russian
- ISSN :
- 24117110 and 18139779
- Volume :
- 15
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Obŝaâ Reanimatologiâ
- Accession number :
- edsair.doi.dedup.....f108907e492e7c3649fc85a820efb928