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Experimental model of atelectasis in newborn piglets

Authors :
Humberto Holmer Fiori
Talitha Comaru
Vinicius Duval da Silva
Renato Machado Fiori
Jaqueline Basso Stivanin
Priscila Padoim
Source :
Respiratory care. 59(1)
Publication Year :
2013

Abstract

BACKGROUND: There are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy. METHODS: Thirteen newborn piglets received artificial mucus injection via the endotracheal tube. X-rays and blood gas analysis confirmed the atelectasis. RESULTS: The model showed consistent results between oxygenation parameters and radiological findings. Ten (76.9%) of the 13 piglets responded to the intervention. This did not significantly differ from the expected percentage of 50% by the binomial test (95% CI 46.2–95%, P = .09). CONCLUSIONS: Our model of atelectasis in newborn piglets is both feasible and appropriate to evaluate the impact of physical therapies on atelectasis in newborns.

Details

ISSN :
19433654
Volume :
59
Issue :
1
Database :
OpenAIRE
Journal :
Respiratory care
Accession number :
edsair.doi.dedup.....f10d85f510a8b301b13fcb542eda1ec8