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Depression induced by chronic stress leads to penile cavernosal dysfunction: protective effect of anti-TNF-α treatment
- Source :
- Canadian journal of physiology and pharmacology. 96(9)
- Publication Year :
- 2018
-
Abstract
- Psychological stress may lead to erectile dysfunction (ED), and inflammation has been evaluated as a major contributing factor. The goal of this study was to investigate the effects of etanercept (ETN), an anti-tumor necrosis factor α (TNF-α) protein, on cavernosal function in the unpredictable chronic mild stress (UCMS) rat model of depression. Animals were divided into 4 groups: animals not exposed to UCMS, animals not exposed to UCMS and treated with ETN, animals exposed to UCMS, and animals treated with ETN while exposed to UCMS. UCMS significantly impaired the neurogenic and endothelium-dependent relaxation responses; reduced cavernosal endothelial nitric oxide (NO) synthase (eNOS) and neuronal NO synthase (nNOS) expressions; decreased testosterone levels; enhanced systemic levels of corticosterone, TNF-α, interleukin 1β (IL-1β), interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1); and also increased cavernosal levels of TNF-α, IL-1β, and IL-6 in rats. ETN administration restored NO-mediated neurogenic and endothelium-dependent relaxation responses of the corpus cavernosum, increased cavernosal eNOS and nNOS expressions, enhanced testosterone levels, and decreased corticosterone levels in UCMS-exposed rats. Also, systemic inflammatory markers and cavernosal proinflammatory cytokine levels were reduced by ETN. Our results demonstrate the role of TNF-α-mediated inflammation in the development of depression and ED in rats exposed to chronic stress.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Nitric Oxide Synthase Type III
Physiology
Inflammation
Nitric Oxide Synthase Type I
medicine.disease_cause
Gene Expression Regulation, Enzymologic
Etanercept
03 medical and health sciences
0302 clinical medicine
Erectile Dysfunction
Physiology (medical)
Internal medicine
medicine
Psychological stress
Animals
Chronic stress
Endothelium
Rats, Wistar
Depression (differential diagnoses)
Pharmacology
030219 obstetrics & reproductive medicine
Behavior, Animal
business.industry
Depression
Tumor Necrosis Factor-alpha
Body Weight
General Medicine
medicine.disease
Rats
Vasodilation
Endocrinology
Erectile dysfunction
Anti tnf α
medicine.symptom
business
030217 neurology & neurosurgery
Locomotion
Stress, Psychological
medicine.drug
Subjects
Details
- ISSN :
- 12057541
- Volume :
- 96
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Canadian journal of physiology and pharmacology
- Accession number :
- edsair.doi.dedup.....f122a79eae69f047b80af8baa6cbacee