Back to Search
Start Over
Statistical inference of risk difference in K correlated 2 x 2 tables with structural zero
- Source :
- Pharmaceutical statistics. 8(4)
- Publication Year :
- 2009
-
Abstract
- K correlated 2 x 2 tables with structural zero are commonly encountered in infectious disease studies. A hypothesis test for risk difference is considered in K independent 2 x 2 tables with structural zero in this paper. Score statistic, likelihood ratio statistic and Wald-type statistic are proposed to test the hypothesis on the basis of stratified data and pooled data. Sample size formulae are derived for controlling a pre-specified power or a pre-determined confidence interval width. Our empirical results show that score statistic and likelihood ratio statistic behave better than Wald-type statistic in terms of type I error rate and coverage probability, sample sizes based on stratified test are smaller than those based on the pooled test in the same design. A real example is used to illustrate the proposed methodologies.
- Subjects :
- Pharmacology
Statistics and Probability
PRESS statistic
Models, Statistical
Pearson's chi-squared test
Biostatistics
Risk Assessment
symbols.namesake
Sampling distribution
F-test
Likelihood-ratio test
Sample Size
Statistics
Ancillary statistic
Test statistic
symbols
Confidence Intervals
Pharmacology (medical)
Computer Simulation
Statistic
Mathematics
Subjects
Details
- ISSN :
- 15391612
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical statistics
- Accession number :
- edsair.doi.dedup.....f125fbd8677a79ac7ec811898b56a2a2