Back to Search
Start Over
Bioavailable testosterone is associated with symptoms of depression in adult men
- Source :
- Journal of International Medical Research, Vol 48 (2020), The Journal of International Medical Research
- Publication Year :
- 2020
- Publisher :
- SAGE Publishing, 2020.
-
Abstract
- ObjectiveThis study aimed to determine the relationship between serum testosterone levels and depressive symptoms in an adult male population.MethodsWe conducted a cross-sectional study of 1166 male participants from Zunyi, Guizhou, China. Each participant completed a questionnaire, a brief clinical exam, and had a fasting blood sample taken. We measured serum testosterone, sex hormone-binding globulin, and luteinizing hormone levels. Multiple linear regression was used to evaluate the effect of demographic factors on the relationship between the depressive symptom score and serum sex hormone levels.ResultsMean testosterone, sex hormone-binding globulin, and luteinizing hormone levels were significantly higher in the depressive symptom group than in the non-depressed group. The mean calculated free serum testosterone level and free testosterone index (FTI) were significantly lower in the depressive symptom group than in the non-depressed group. Additionally, the mean FTI was significantly negatively correlated with the Beck Depression Inventory scale score in the multiple linear regression model (95% confidence interval: −3.274 to −0.406).ConclusionsDecreased bioactive testosterone levels might be a contributing factor of depression in adult men. The FTI could be the most sensitive biomarker reflecting the level of bioavailable testosterone in patients with depression.
- Subjects :
- Adult
Male
China
Medicine (General)
Adult male
030232 urology & nephrology
Physiology
adult men
030209 endocrinology & metabolism
free testosterone index
Biochemistry
Beck Depression Inventory scale
Pre-Clinical Research Report
sex hormone
03 medical and health sciences
0302 clinical medicine
Sex hormone-binding globulin
R5-920
Sex Hormone-Binding Globulin
Humans
Medicine
Testosterone
Depressive symptoms
Depression (differential diagnoses)
Serum testosterone
biology
Depression
business.industry
Biochemistry (medical)
Cell Biology
General Medicine
Cross-Sectional Studies
Bioavailable Testosterone
luteinizing hormone
biology.protein
business
Luteinizing hormone
Subjects
Details
- Language :
- English
- ISSN :
- 14732300
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....f1420d44e80b33e6dba892d655a4a846