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Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
- Source :
- Pediatric research
- Publication Year :
- 2017
-
Abstract
- The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. We conducted a cross-sectional pilot study of 10–13 y old healthy children. We assessed descriptive, univariable, and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction. Possible associations with brachial artery distensibility, pulse wave velocity (markers of vascular stiffness), and serum endothelial cell-derived microparticle levels were also assessed. We enrolled 41 participants, 12.1 ± 1.0 y, most of whom were Mexican Americans (42%) or other Hispanics (34%). Increased BPA levels were associated with increased levels of F2-isoprostane (ng/ml) (P = 0.02), with a similar trend for DEHP metabolites. Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with a 0.550 increase in Homeostatic Model Assessment of insulin resistance (HOMA-IR) units (P = 0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P = 0.026). Bisphenol S (BPS), a replacement for BPA, was associated with increased albumin (mg):creatinine (g) ratio (P = 0.04). Metabolites of HMW phthalates were also associated with decreased brachial artery distensibility (P = 0.047). Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children.
- Subjects :
- Male
medicine.medical_specialty
endocrine system
Adolescent
Pilot Projects
010501 environmental sciences
01 natural sciences
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Phenols
Internal medicine
medicine.artery
Diethylhexyl Phthalate
medicine
Humans
030212 general & internal medicine
Endothelial dysfunction
Brachial artery
Benzhydryl Compounds
Child
Pulse wave velocity
0105 earth and related environmental sciences
Creatinine
business.industry
Phthalate
medicine.disease
3. Good health
Oxidative Stress
Endocrinology
Cross-Sectional Studies
chemistry
Pediatrics, Perinatology and Child Health
Albuminuria
Homeostatic model assessment
Female
Endothelium, Vascular
medicine.symptom
Insulin Resistance
business
Subjects
Details
- Language :
- English
- ISSN :
- 15300447 and 00313998
- Volume :
- 81
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pediatric research
- Accession number :
- edsair.doi.dedup.....f14697c02f03ef75784ec833d2f88144