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Usefulness of skin advanced glycation end products to predict coronary artery calcium score in patients with type 2 diabetes
- Source :
- Acta Diabetologica. 58:1403-1412
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The early identification of type 2 diabetic (T2D) patients at risk of developing coronary artery disease (CAD) remains a challenge. The coronary artery calcium score (CACs) is considered the most sensitive tool for assessing CAD risk in diabetic population, and the identification of a more targeted population in which the CACs would be more cost-efficient seems warranted. The accumulation of advanced glycation end products plays an important role in the pathogenesis of cardiovascular disease (CVD) in patients with diabetes. The aim of this study was to evaluate whether the assessment of skin autofluorescence (SAF) could be useful tool to identify those diabetic patients in whom CACs assessment should be prioritized. Prospective case–control study, comprising 156 subjects with T2D with no history of clinical CVD and 52 non-diabetic subjects matched by age. A value of CACs ≥ 400 Agatston Units (AU) was considered as “high CVD risk.” Logistic regression analysis to predict a CACs ≥ 400 AU was performed. Sensibility and specificity were calculated using the optimal cutoff point based on ROC curve. T2D patients had higher value of SAF compared to controls (p = 0.011). Among subjects with diabetes, 122 presented CACs
- Subjects :
- Glycation End Products, Advanced
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Population
030209 endocrinology & metabolism
Type 2 diabetes
Disease
030204 cardiovascular system & hematology
Logistic regression
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Endocrinology
Risk Factors
Glycation
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
cardiovascular diseases
education
education.field_of_study
Coronary artery calcium score
business.industry
nutritional and metabolic diseases
General Medicine
medicine.disease
Coronary Vessels
Diabetes Mellitus, Type 2
Case-Control Studies
cardiovascular system
Cardiology
population characteristics
Calcium
business
Subjects
Details
- ISSN :
- 14325233 and 09405429
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica
- Accession number :
- edsair.doi.dedup.....f14ae2353a7514fbdff6f12905cf0c37