Back to Search
Start Over
Novel Lipid and Preservative-free Propofol Formulation: Properties and Pharmacodynamics
- Source :
- Pharmaceutical Research. 25:313-319
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Propofol is a water-insoluble intravenous anesthetic agent that is actually formulated as a water-in-oil emulsion with known drawbacks such as pain on injection, microorganism growth support and stability. We report on the properties of formulations of propofol in poly (N-vinyl-2-pyrrolidone)-block-poly(d,l-lactide), PVP–PLA, polymeric micelles (Propofol-PM). Microbial growth in these formulations was evaluated with Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922) and Candida albicans (ATCC 10231). Sleep-recovery studies in female Sprague–Dawley rats, at a dose of 10mg/kg were performed to compare pharmacodynamic profiles of the new Propofol-PM formulations with those of Diprivan®, a commercially available lipid based propofol formulation. Growth of microorganisms was not supported in the Propofol-PM formulations tested. No significant differences in times to unconsciousness, awakening, recovery of righting reflex and full recovery were observed between Propofol-PM formulations and Diprivan®. Propofol loaded in PVP–PLA micelles (Propofol-PM) is not significantly different in terms of pharmacodynamic but demonstrates no microorganism growth support and improved stability that opens up the door to pain on injection reduction strategy.
- Subjects :
- Chemistry, Pharmaceutical
Colony Count, Microbial
Pharmaceutical Science
Pharmacology
Bacterial growth
medicine.disease_cause
Micelle
Rats, Sprague-Dawley
Drug Stability
medicine
Animals
Organic chemistry
Pharmacology (medical)
Particle Size
Candida albicans
Propofol
biology
Chemistry
Organic Chemistry
Biological activity
biology.organism_classification
Rats
Staphylococcus aureus
Pharmacodynamics
Emulsion
Molecular Medicine
Female
Sleep
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 1573904X and 07248741
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Research
- Accession number :
- edsair.doi.dedup.....f14c62d4e076c8cd0791e646a22a442e
- Full Text :
- https://doi.org/10.1007/s11095-007-9471-5