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Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
- Source :
- Magnetic Resonance Insights, Vol 7 (2014), Magnetic Resonance Insights, Vol 2014, Iss 7, Pp 23-31 (2014), Magnetic Resonance Insights
- Publication Year :
- 2014
- Publisher :
- SAGE Publishing, 2014.
-
Abstract
- Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)–experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximately 20 days after induction. Hematoxylin and eosin, solochrome cyanin–stained sections, and EM images were obtained from the optic chiasms of some mice approximately 4 days after disease onset when their scores were thought to be the highest. T2-weighted imaging and apparent diffusion coefficient map hyperintensities corresponded to abnormalities in the optic chiasms of EAE mice. Mixed inflammation was concentrated at the lateral surface. Degeneration of oligodendrocytes, myelin, and early axonal damage were also apparent. A marked increase in chiasm thickness was observed. T2-weighted and diffusion-weighted MRI can detect abnormalities in the optic chiasms of MOG-EAE mice. MRI is an important method in the study of this model toward understanding optic neuritis.
- Subjects :
- lcsh:Medical physics. Medical radiology. Nuclear medicine
Pathology
medicine.medical_specialty
lcsh:R895-920
experimental autoimmune encephalomyelitis
H&E stain
Optic chiasm
Myelin oligodendrocyte glycoprotein
03 medical and health sciences
Myelin
0302 clinical medicine
medicine
magnetic resonance imaging
Optic neuritis
mouse
Original Research
030304 developmental biology
0303 health sciences
pertussis toxin
biology
medicine.diagnostic_test
business.industry
optic chiasm
Experimental autoimmune encephalomyelitis
Magnetic resonance imaging
medicine.disease
Hyperintensity
medicine.anatomical_structure
biology.protein
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance Insights
- Accession number :
- edsair.doi.dedup.....f151a3d4bfedb5bb24e85b9496705963