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Salivary immunity and lower respiratory tract infections in non-elite marathon runners
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), PLoS ONE, Vol 13, Iss 11, p e0206059 (2018), Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS One, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, PLoS ONE
- Publication Year :
- 2018
-
Abstract
- Rationale Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. Methods Forty seven healthy marathon runners (28 males and 19 females) who completed the 42.195 km of the 2016 Barcelona marathon were studied. Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, antimicrobial proteins (lactoferrin, lysozyme) and chemokines (Gro alpha, Gro beta, MCP-1) were determined using ELISA kits in saliva supernatant. Blood biochemistry and haemogram were analyzed in all participants. The presence of LRTI was considered in those runners who reported infectious lower respiratory tract symptoms during a minimum of 3 consecutive days in the 2 weeks after the race. Results Eight participants (17%) presented a LRTI during the 2 weeks of follow-up. Higher lysozyme levels were detected after the race in runners with LRTI when compared with those without infection. A decrease in salivary lysozyme, Gro alpha and Gro beta levels after the race were observed in those runners who did not develop a LRTI when compared to basal levels. Salivary Gro alpha levels correlated with basophil blood counts, and salivary lysozyme levels correlated with leukocyte blood counts. Conclusions LRTI are common after a marathon race in non-elite healthy runners. Changes in salivary antimicrobial proteins and chemokines are related to the presence of LRTI and correlate with systemic defense cells, which suggest an important role of salivary immunity in the development of LRTI in non-elite marathon runners.
- Subjects :
- Male
Saliva
Pulmonology
Physiology
lcsh:Medicine
Basophil
Biochemistry
Running
White Blood Cells
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Respiratory system
lcsh:Science
Respiratory Tract Infections
Multidisciplinary
Respiratory tract infections
biology
Lactoferrin
Chemotaxis
Enginyeria biomèdica [Àrees temàtiques de la UPC]
Enzymes
Body Fluids
Basophils
Lower Respiratory Tract Infections
Cell Motility
Blood
medicine.anatomical_structure
Female
Enginyeria biomèdica
Chemokines
Anatomy
Cellular Types
Biomedical engineering
Research Article
Adult
Immune Cells
Lysozyme
Immunology
education
03 medical and health sciences
Immunity
medicine
Humans
Blood Cells
business.industry
Blood biochemistry
lcsh:R
Biology and Life Sciences
Proteins
Cell Biology
030229 sport sciences
Immunoglobulin A
respiratory tract diseases
Respiratory Infections
Enzymology
biology.protein
Muramidase
lcsh:Q
business
human activities
030217 neurology & neurosurgery
Respiratory tract
Subjects
Details
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), PLoS ONE, Vol 13, Iss 11, p e0206059 (2018), Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS One, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, PLoS ONE
- Accession number :
- edsair.doi.dedup.....f170612540a936416ebac69dfda1b216