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Investigation of T2-weighted signal intensity of infarcted myocardium and its correlation with delayed enhancement magnetic resonance imaging in a porcine model with reperfused acute myocardial infarction
- Source :
- The International Journal of Cardiovascular Imaging. 25:111-119
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- To assess the signal pattern in T2-weighted images (T2WI) and determine its relation to persistent microvascular obstruction (PMO) and intramyocardial hemorrhage in a porcine model with reperfused acute myocardial infarction. Left anterior descending artery was occluded (90 or 180 min) and reperfused (90 min). T2WI and delayed-enhanced magnetic resonance images (DE-MRI) were acquired. The T2WI signal pattern, T2WI contrast ratio, PMO, and intramyocardial hemorrhage were evaluated, and their interrelationships were analyzed. The infarct area on T2WI was recorded as a homogeneous high-intensity signal or as low- or iso-intensity signals. The contrast ratio of the T2WI in the cases with PMO was significantly lower than that in those without PMO (1.38 ± 0.25 vs. 1.89 ± 0.31, P < 0.05), and it showed significant inverse correlation with the extent of PMO observed in DE-MRI images (r =−0.8, P < 0.05). The extent of PMO correlated strongly with that of intramyocardial hemorrhage (r = 0.97, P < 0.05). The abnormal signal area in the T2WI was larger than the infarct area in the DE-MRI images (47.0 ± 9.9% vs. 37.8 ± 9.9%, P < 0.05) and the infarct area observed after TTC staining (47.0 ± 9.9% vs. 37.4 ± 8.4%, P < 0.05). We observed variable T2WI signal patterns for the infarcted myocardium. Lower T2WI contrast ratios significantly correlated with the extent of PMO in DE-MRI and intramyocardial hemorrhage in the gross specimen.
- Subjects :
- medicine.medical_specialty
Swine
Myocardial Infarction
Contrast Media
Hemorrhage
Myocardial Reperfusion
Delayed enhancement
Severity of Illness Index
Microcirculation
Correlation
Coronary circulation
Coronary Circulation
Internal medicine
medicine
Animals
Radiology, Nuclear Medicine and imaging
Myocardial infarction
Cardiac imaging
medicine.diagnostic_test
business.industry
Myocardium
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Disease Models, Animal
medicine.anatomical_structure
Cardiology
Cardiology and Cardiovascular Medicine
business
Artery
Subjects
Details
- ISSN :
- 15730743 and 15695794
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- The International Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....f17290231ab65b338ccec0aeb6ab2fae