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Impact of Aldehyde Dehydrogenase Activity on Gliomas
- Source :
- Trends in Pharmacological Sciences. 39:605-609
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- High-grade gliomas are primary brain tumors with a highly aggressive, invasive phenotype and dismal outcome. Targeting cell metabolism and cancer bioenergetics has emerged as a potential effective therapeutic approach. Selective aldehyde dehydrogenase isoenzyme activity regulates glioma tumor growth, invasiveness, and resistance to current treatments, and has potential as a therapeutic target.
- Subjects :
- Bioenergetics
Aldehyde dehydrogenase
Toxicology
03 medical and health sciences
Therapeutic approach
0302 clinical medicine
Cell Line, Tumor
Glioma
Animals
Humans
Medicine
Neoplasm Invasiveness
Primary Brain Tumors
neoplasms
Cell Proliferation
Pharmacology
biology
Brain Neoplasms
business.industry
Aldehyde dehydrogenase isoenzyme
Cancer
Aldehyde Dehydrogenase
medicine.disease
Isoenzymes
Cell metabolism
030220 oncology & carcinogenesis
biology.protein
Cancer research
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01656147
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Trends in Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....f1827ee115d3f5167cad8f30da2cbf59