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The interplay between innate lymphoid cells and T cells
- Source :
- Mucosal Immunology, Mucosal Immunology, Nature Pub. Group, 2020, ⟨10.1038/s41385-020-0320-8⟩, Mucosal Immunology, 2020, ⟨10.1038/s41385-020-0320-8⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; ILCs and T cells are closely related functionally but they significantly differ in their ability to circulate, expand, and renew. Cooperation and reciprocal functional regulation suggest that these cell types are more complementary than simply redundant during immune responses. How ILCs shape T-cell responses is strongly dependent on the tissue and inflammatory context. Likewise, indirect regulation of ILCs by adaptive immunity is induced by environmental cues such as the gut microbiota. Here, we review shared requirements for the development and function of both cell types and divergences in the orchestration of prototypic immune functions. We discuss the diversity of functional interactions between T cells and ILCs during homeostasis and immune responses. Identifying the location and the nature of the tissue microenvironment in which these interactions are taking place may uncover the remaining mysteries of their close encounters.
- Subjects :
- 0301 basic medicine
Cell type
[SDV.IMM] Life Sciences [q-bio]/Immunology
Immunology
Context (language use)
Cell Communication
Biology
Gut flora
Adaptive Immunity
Lymphocyte Activation
Substrate Specificity
Immunomodulation
03 medical and health sciences
0302 clinical medicine
Immune system
T-Lymphocyte Subsets
Immunology and Allergy
Animals
Humans
skin and connective tissue diseases
Immunity, Cellular
Innate lymphoid cell
Cell Differentiation
Acquired immune system
biology.organism_classification
Immunity, Innate
body regions
030104 developmental biology
Gene Expression Regulation
Host-Pathogen Interactions
[SDV.IMM]Life Sciences [q-bio]/Immunology
Neuroscience
Immunologic Memory
Function (biology)
Homeostasis
Biomarkers
030215 immunology
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 19330219 and 19353456
- Database :
- OpenAIRE
- Journal :
- Mucosal Immunology, Mucosal Immunology, Nature Pub. Group, 2020, ⟨10.1038/s41385-020-0320-8⟩, Mucosal Immunology, 2020, ⟨10.1038/s41385-020-0320-8⟩
- Accession number :
- edsair.doi.dedup.....f18c1392c4e543acb8007125073b4a0a