Back to Search
Start Over
Neuron–Glia Interaction in the Suprachiasmatic Nucleus: A Double Labeling Light and Electron Microscopic Immunocytochemical Study in the Rat
- Source :
- Brain Research Bulletin. 45:281-287
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- The morphological interactions between astroglial and neuronal elements were elucidated in the rat suprachiasmatic nucleus (SCN) by light and electron microscopic immunocytochemistry using antibodies against glial fibrillary acidic protein (GFAP), vasoactive intestinal peptide (VIP) and arginine-vasopressin (AVP). Throughout the SCN, particularly in its ventral portion, GFAP-like-immunoreactive (GFAP-LI) astroglial elements were found. These astrocytes displaying GFAP-like immunoreactivity occasionally contained fairly well-developed organelles. Some of these astrocytes were found as satellite cells in close contact with non-immunoreactive neuronal perikarya and processes. Around the neurons, GFAP-LI astroglial processes were also observed to cover some portions of presynaptic and postsynaptic elements. In addition, these astroglial elements were seen between two neuronal somata and pericytes of blood capillaries as glial endfeet. By double labeling immunoelectron microscopy using antibodies against GFAP/VIP and GFAP/AVP, some portions of VIP-like-immunoreactive or AVP-like-immunoreactive neuronal somata and processes were found to be engulfed by GFAP-LI astroglial processes. The possible functional roles of the morphological interactions between astroglial and neuronal elements are discussed.
- Subjects :
- Male
Immunoelectron microscopy
Vasoactive intestinal peptide
Immunocytochemistry
Cell Communication
Glial Fibrillary Acidic Protein
medicine
Animals
Rats, Wistar
Neurons
Glial fibrillary acidic protein
biology
Suprachiasmatic nucleus
General Neuroscience
Immunohistochemistry
Rats
Cell biology
Arginine Vasopressin
Microscopy, Electron
medicine.anatomical_structure
nervous system
Astrocytes
biology.protein
Neuroglia
Suprachiasmatic Nucleus
Neuron
Neuroscience
hormones, hormone substitutes, and hormone antagonists
Vasoactive Intestinal Peptide
Astrocyte
Subjects
Details
- ISSN :
- 03619230
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Brain Research Bulletin
- Accession number :
- edsair.doi.dedup.....f1a0752204810add00869dc3f91333cb