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Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017), Nature Communications, Nature
- Publication Year :
- 2017
-
Abstract
- Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behaviour. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical stresses. However, the field is currently held back by the limitations of the available methods to apply physiologically relevant stress profiles on cells, particularly with sub-cellular resolution, in controlled in vitro experiments. Here we report a new type of active cell culture material that allows highly localized, directional and reversible deformation of the cell growth substrate, with control at scales ranging from the entire surface to the subcellular, and response times on the order of seconds. These capabilities are not matched by any other method, and this versatile material has the potential to bridge the performance gap between the existing single cell micro-manipulation and 2D cell sheet mechanical stimulation techniques.<br />United States. Department of Energy (DE-SC0005247)<br />United States. Office of Naval Research (N00014-15-1-2157)
- Subjects :
- 0301 basic medicine
Light
Cellular differentiation
Science
Cell
Acrylic Resins
Cell Culture Techniques
General Physics and Astronomy
Nanotechnology
Mechanotransduction, Cellular
General Biochemistry, Genetics and Molecular Biology
Cell Line
Stress (mechanics)
03 medical and health sciences
Mice
medicine
Animals
Mechanotransduction
Fluorescent Dyes
Multidisciplinary
Nanotubes
ta114
Cell growth
Optical Imaging
fungi
Temperature
Cell Differentiation
Hydrogels
Mesenchymal Stem Cells
General Chemistry
Fluoresceins
Photochemical Processes
Corrigenda
In vitro
030104 developmental biology
medicine.anatomical_structure
Cell culture
Gold
Stress, Mechanical
Hybrid material
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- NATURE COMMUNICATIONS
- Accession number :
- edsair.doi.dedup.....f1c1d60cabe487bc2cf8e77552f5a3a9