Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release. Fil: Dedic, Nina. Max Planck Institute Of Psychiatry; Alemania Fil: Kühne, Claudia. Max Planck Institute Of Psychiatry; Alemania Fil: Jakovcevski, Mira. Max Planck Institute Of Psychiatry; Alemania Fil: Hartmann, Jakob. Max Planck Institute Of Psychiatry; Alemania Fil: Genewsky, Andreas J.. Max Planck Institut Of Psychiatry; Alemania Fil: Gomes, Karina S.. Max Planck Institute Of Psychiatry; Alemania Fil: Anderzhanova, Elmira. Max Planck Institute Of Psychiatry; Alemania Fil: Pöhlmann, Max L.. Max Planck Institute Of Psychiatry; Alemania Fil: Chang, Simon. Max Planck Institute Of Psychiatry; Alemania Fil: Kolarz, Adam. Max Planck Institute Of Psychiatry; Alemania Fil: Vogl, Annette M.. Max Planck Institute Of Psychiatry; Alemania Fil: Dine, Julien. Max Planck Institute Of Psychiatry; Alemania Fil: Metzger, Michael W.. Max Planck Institute of Psychiatry; Armenia Fil: Schmid, Bianca. Max Planck Institute Of Psychiatry; Alemania Fil: Almada, Rafael C.. Max Planck Institute Of Psychiatry; Alemania Fil: Ressler, Kerry J.. Harvard Medical School; Estados Unidos Fil: Wotjak, Carsten T.. Max Planck Institute Of Psychiatry; Alemania Fil: Grinevich, Valery. University of Heidelberg; Alemania Fil: Chen, Alon. Max Planck Institute Of Psychiatry; Alemania Fil: Schmidt, Mathias V.. Institute Of Developmental Genetics, Helmholtz Zentrum; Alemania Fil: Wurst, Wolfgang. German Center for Neurodegenerative Diseases; Alemania Fil: Refojo, Damian. Max Planck Institute Of Psychiatry; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Deussing, Jan M.. Max Planck Institute Of Psychiatry; Alemania