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Long-term oncologic safety of immediate reconstructive surgery in patients with invasive breast cancer: a retrospective matched-cohort study
- Source :
- World Journal of Surgical Oncology, World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-13 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Objective Immediate reconstruction (IR) is a safe and effective surgical treatment for patients with breast cancer. We aimed to assess the prognosis, aesthetic outcomes, and patient satisfaction of IR compared with breast conservation surgery (BCS) and total mastectomy (TM). Methods This retrospective matched-cohort study was conducted between May 2005 and December 2014. We established two cohorts according to the tumor (T) size of breast cancer. In the T≤3cm group, cases (IR) and controls (BCS or TM) were matched for age, pathological tumor size, and pathologic nodal status in a 1:1:1 ratio. In the T>3cm group, cases (IR) and controls (TM) were matched with the same factors and ratio. The primary outcome was the 5-year disease-free survival (DFS). The secondary outcome was patient satisfaction and quality of life. Results A total of 12,678 breast cancer patients were assessed for eligibility, of which 587 were included (T≤3 cm group: 155 IR vs 155 BCS vs 155 TM; T>3cm group: 61 IR vs 61 TM). In the T≤3 cm cohort, patients who underwent IR had no difference compared with those who underwent BCS or TM regarding the 5-year DFS (P=0.539); however, an improved aesthetic satisfaction, psychosocial, and sexual well-being were achieved in the IR group (P3 cm cohort, the IR group had a worse median 5-year DFS (P=0.044), especially for Her2+ or triple-negative breast carcinoma (TNBC) subtypes compared with the TM group. Conclusions IR improves aesthetic satisfaction, psychosocial, and sexual well-being for breast cancer patients with T≤3 cm. For patients with T > 3 cm invasive breast cancer, TM is superior to IR as it predicts a better 5-year DFS.
- Subjects :
- Reconstructive surgery
medicine.medical_specialty
RD1-811
Modified radical mastectomy
Breast Neoplasms
Cohort Studies
Matched cohort
Breast cancer
Humans
Medicine
Breast conservation surgery
In patient
Breast reconstruction
RC254-282
Mastectomy
Retrospective Studies
business.industry
Research
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Patient satisfaction
Plastic Surgery Procedures
medicine.disease
Prognosis
Term (time)
Surgery
Oncology
Quality of Life
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 14777819
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....f1f291e1b68151387e60ef6d1c1a4a74