Back to Search
Start Over
Statistical modeling of heart rate variability to unravel the factors affecting autonomic regulation in preterm infants
- Source :
- Scientific Reports, 9(1):7691. Nature Publishing Group, Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
- Publication Year :
- 2019
-
Abstract
- Analyzing heart rate variability (HRV) in preterm infants can help track maturational changes and subclinical signatures of disease. We conducted an observational study to characterize the effect of demographic and cardiorespiratory factors on three features of HRV using a linear mixed-effects model. HRV-features were tailored to capture the unique physiology of preterm infants, including the contribution of transient pathophysiological heart rate (HR) decelerations. Infants were analyzed during stable periods in the incubator and subsequent sessions of Kangaroo care (KC) – an intervention that increases comfort. In total, 957 periods in the incubator and during KC were analyzed from 66 preterm infants. Our primary finding was that gestational age (GA) and postmenstrual age (PMA) have the largest influence on HRV while the HR and breathing rate have a considerably smaller effect. Birth weight and gender do not affect HRV. We identified that with increasing GA and PMA, overall HRV decreased and increased respectively. Potentially these differences can be attributed to distinct trajectories of intra- and extrauterine development. With increasing GA, the propensity towards severe HR decelerations decreases, thereby reducing overall variability, while with increasing PMA, the ratio of decelerations and accelerations approaches unity, increasing overall HRV.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Incubators, Infant
Respiratory rate
Birth weight
lcsh:Medicine
Gestational Age
Infant, Premature, Diseases
Predictive markers
Autonomic Nervous System
Article
03 medical and health sciences
0302 clinical medicine
Respiratory Rate
Heart Rate
Internal medicine
Heart rate
medicine
Bradycardia
Heart rate variability
Birth Weight
Humans
lcsh:Science
Kangaroo care
Multidisciplinary
business.industry
lcsh:R
Postmenstrual Age
Infant, Newborn
Models, Cardiovascular
Gestational age
Cardiorespiratory fitness
Infant, Low Birth Weight
Kangaroo-Mother Care Method
030104 developmental biology
Infant, Extremely Low Birth Weight
Infant, Extremely Premature
Cardiology
lcsh:Q
Female
business
Biomedical engineering
030217 neurology & neurosurgery
Algorithms
Infant, Premature
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, 9(1):7691. Nature Publishing Group, Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
- Accession number :
- edsair.doi.dedup.....f20233d36ebc7b4029439703121fdd53