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Author Correction: 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Lysosome membrane permeabilization (LMP) has been implicated in cell death. In the present study, we investigated the relationship between cell death and H2O2-/CCl4-induced LMP in hepatocytes in vitro and following acute liver injury in vivo. The key finding was that H2O2 triggered LMP by oxidative stress, as evidenced by a suppression of LAMP1 expression, a reduction in LysoTracker Green and AO staining, and the leakage of proton and cathepsin B/D from the lysosome to the cytoplasm, resulting in cell death. CCl4 also triggered hepatocyte death by decreasing lysosome LAMP1 expression and by inducing the accumulation of products of peroxidative lipids and oxidized proteins. Furthermore, a novel compound 5,8-dimethoxy-6-methyl-7-hydroxy-3-3(2-hydroxy-4-methoxybenzyl) chroman-4-one (58-F) was extracted from Ophiopogon japonicus and served as a potential therapeutic drug. In vivo and in vitro results showed that 58-F effectively rescued hepatocytes by decreasing LMP and by inducing lysosomal enzyme translocation to the cytosol.
- Subjects :
- Lysosomal membrane
Science
Ophiopogon japonicus
Permeability
chemistry.chemical_compound
Mice
medicine
Animals
Author Correction
Mice, Inbred BALB C
Multidisciplinary
biology
Cell Death
Carbon Tetrachloride Poisoning
Ophiopogon
Hydrogen Peroxide
Intracellular Membranes
biology.organism_classification
Flavones
Molecular biology
medicine.anatomical_structure
chemistry
Permeability (electromagnetism)
Hepatocyte
Hepatocytes
Medicine
Lysosomes
Flavanone
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....f215af64cef63ec4361993c32989f8ff