Back to Search
Start Over
Differences in lipidomics may be potential biomarkers for early diagnosis of pancreatic cancer
- Source :
- Acta Cirúrgica Brasileira v.35 n.5 2020, Acta Cirúrgica Brasileira, Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC), instacron:SBDPC, Acta Cirurgica Brasileira, Volume: 35, Issue: 5, Article number: e202000508, Published: 06 JUL 2020, Acta Cirurgica Brasileira, Vol 35, Iss 5 (2020)
- Publication Year :
- 2020
- Publisher :
- Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2020.
-
Abstract
- Purpose To analyze the plasma lipid spectrum between healthy control and patients with pancreatic cancer and to select differentially expressed tumor markers for early diagnosis. Methods In total, 20 patents were divided into case group and healthy control group according to surgical pathology. Of almost 1206 plasma lipid molecules harvested from 20 patients were measured by HILIC using the normal phase LC/MS. Heat map presented the relative levels of metabolites and lipids in the healthy control group and patients with pancreatic cancer. The PCA model was constructed to find out the difference in lipid metabolites. The principal components were drawn in a score plot and any clustering tendency could be observed. PLS-DA were performed to distinguish the healthy control group and pancreatic cancer according to the identified lipid profiling datasets. The volcano plot was used to visualize all variables with VIP>1 and presented the important variables with P2. Results The upregulated lipid metabolites in patients with pancreatic cancer contained 9 lipids; however, the downregulated lipid metabolites contained 79 lipids. Conclusion There were lipid metabolomic differences in patients with pancreatic cancer, which could serve as potential tumor markers for pancreatic cancer.
- Subjects :
- medicine.medical_specialty
RD1-811
Clustering tendency
Gastroenterology
Surgical pathology
03 medical and health sciences
0302 clinical medicine
Metabolomics
Internal medicine
Pancreatic cancer
Lipidomics
Diagnosis
Biomarkers, Tumor
Medicine
Humans
Lipid profiling
In patient
Early Detection of Cancer
business.industry
medicine.disease
Lipids
Pancreatic Neoplasms
030220 oncology & carcinogenesis
Potential biomarkers
lipids (amino acids, peptides, and proteins)
030211 gastroenterology & hepatology
Surgery
Erratum
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Acta Cirúrgica Brasileira v.35 n.5 2020, Acta Cirúrgica Brasileira, Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC), instacron:SBDPC, Acta Cirurgica Brasileira, Volume: 35, Issue: 5, Article number: e202000508, Published: 06 JUL 2020, Acta Cirurgica Brasileira, Vol 35, Iss 5 (2020)
- Accession number :
- edsair.doi.dedup.....f239f3cac30044d3d85cc632ce139c39