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Reduced L-arginine transport contributes to the pathogenesis of myocardial ischemia-reperfusion injury
- Source :
- Journal of cellular biochemistry. 108(1)
- Publication Year :
- 2009
-
Abstract
- Myocardial injury due to ischemia-reperfusion (I-R) damage remains a major clinical challenge. Its pathogenesis is complex including endothelial dysfunction and heightened oxidative stress although the key driving mechanism remains uncertain. In this study we tested the hypothesis that the I-R process induces a state of insufficient L-arginine availability for NO biosynthesis, and that this is pivotal in the development of myocardial I-R damage. In neonatal rat ventricular cardiomyocytes (NVCM), hypoxia-reoxygenation significantly decreased L-arginine uptake and NO production (42 ± 2% and 71 ± 4%, respectively, both P
- Subjects :
- medicine.medical_specialty
TRPV Cation Channels
Myocardial Reperfusion Injury
medicine.disease_cause
Arginine
Nitric Oxide
Transfection
Biochemistry
Pathogenesis
Rats, Sprague-Dawley
chemistry.chemical_compound
Mice
Oxygen Consumption
Internal medicine
Lactate dehydrogenase
Troponin I
medicine
Animals
Myocytes, Cardiac
Endothelial dysfunction
Inner mitochondrial membrane
Molecular Biology
business.industry
Nitrotyrosine
Cell Biology
medicine.disease
Rats
Endocrinology
chemistry
business
Reperfusion injury
Oxidative stress
Subjects
Details
- ISSN :
- 10974644
- Volume :
- 108
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of cellular biochemistry
- Accession number :
- edsair.doi.dedup.....f24a1c1adad4befff3a81411631c69f3