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Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Eur J Clin Microbiol Infect Dis, European Journal of Clinical Microbiology & Infectious Diseases
- Publication Year :
- 2020
- Publisher :
- Springer, 2020.
-
Abstract
- An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p
- Subjects :
- Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Community-acquired pneumonia
030106 microbiology
Antimicrobial treatment
Prevalence
Guideline
Settore MED/10 - Malattie Dell'Apparato Respiratorio
Guidelines
Global Health
medicine.disease_cause
Immunocompromised Host
03 medical and health sciences
0302 clinical medicine
Medical microbiology
Internal medicine
Epidemiology
Streptococcus pneumoniae
Pneumonia, Bacterial
Humans
Medicine
030212 general & internal medicine
Practice Patterns, Physicians'
Aged
Aged, 80 and over
business.industry
Correction
General Medicine
Middle Aged
medicine.disease
Anti-Bacterial Agents
Community-Acquired Infections
Hospitalization
Pneumonia
Infectious Diseases
Practice Guidelines as Topic
Pseudomonas aeruginosa
Etiology
Original Article
Female
Guideline Adherence
business
Subjects
Details
- Language :
- English
- ISSN :
- 09349723
- Database :
- OpenAIRE
- Journal :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Eur J Clin Microbiol Infect Dis, European Journal of Clinical Microbiology & Infectious Diseases
- Accession number :
- edsair.doi.dedup.....f268fb65f17fccdcbcaf60fac1b90c6b