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The Dual Role of MicroRNAs in Colorectal Cancer Progression
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 19, Iss 9, p 2791 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Colorectal cancer (CRC) is responsible for one of the major cancer incidence and mortality worldwide. It is well known that MicroRNAs (miRNAs) play vital roles in maintaining the cell development and other physiological processes, as well as, the aberrant expression of numerous miRNAs involved in CRC progression. MiRNAs are a class of small, endogenous, non-coding, single-stranded RNAs that bind to the 3’-untranslated region (3′-UTR) complementary sequences of their target mRNA, resulting in mRNA degradation or inhibition of its translation as a post-transcriptional regulators. Moreover, miRNAs also can target the long non-coding RNA (lncRNA) to regulate the expression of its target genes involved in proliferation and metastasis of CRC. The functions of these dysregulated miRNAs appear to be context specific, with evidence of having a dual role in both oncogenes and tumor suppression depending on the cellular environment in which they are expressed. Therefore, the unique expression profiles of miRNAs relate to the diagnosis, prognosis, and therapeutic outcome in CRC. In this review, we focused on several oncogenic and tumor-suppressive miRNAs specific to CRC, and assess their functions to uncover the molecular mechanisms of tumor initiation and progression in CRC. These data promised that miRNAs can be used as early detection biomarkers and potential therapeutic target in CRC patients.
- Subjects :
- 0301 basic medicine
Colorectal cancer
Review
Tumor initiation
Biology
colorectal cancer (CRC)
Catalysis
Metastasis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
tumor-suppressive miRNAs
0302 clinical medicine
microRNA
Biomarkers, Tumor
medicine
Animals
Humans
RNA, Messenger
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Gene
Spectroscopy
oncogenic miRNAs
Cell growth
Organic Chemistry
biomarkers
RNA
Translation (biology)
General Medicine
Prognosis
medicine.disease
Computer Science Applications
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
Disease Progression
Cancer research
RNA, Long Noncoding
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....f292f3e48091023ebdc691b790bb4b32