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ADP-Ribosylation as Post-Translational Modification of Proteins: Use of Inhibitors in Cancer Control
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 10829, p 10829 (2021), International journal of molecular sciences (Online) 22 (2021): 829. doi:10.3390/ijms221910829, info:cnr-pdr/source/autori:Poltronieri P.; Miwa M.; Masutani M./titolo:ADP-ribosylation as post-translational modification of proteins: use of inhibitors in cancer control/doi:10.3390%2Fijms221910829/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:829/pagina_a:/intervallo_pagine:829/volume:22, International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Among the post-translational modifications of proteins, ADP-ribosylation has been studied for over fifty years, and a large set of functions, including DNA repair, transcription, and cell signaling, have been assigned to this post-translational modification (PTM). This review presents an update on the function of a large set of enzyme writers, the readers that are recruited by the modified targets, and the erasers that reverse the modification to the original amino acid residue, removing the covalent bonds formed. In particular, the review provides details on the involvement of the enzymes performing monoADP-ribosylation/polyADP-ribosylation (MAR/PAR) cycling in cancers. Of note, there is potential for the application of the inhibitors developed for cancer also in the therapy of non-oncological diseases such as the protection against oxidative stress, the suppression of inflammatory responses, and the treatment of neurodegenerative diseases. This field of studies is not concluded, since novel enzymes are being discovered at a rapid pace.
- Subjects :
- Poly Adenosine Diphosphate Ribose
Cell signaling
macro-domain (MACRO)
QH301-705.5
DNA repair
Poly (ADP-Ribose) Polymerase-1
ADP-ribose hydrolase (ARH)
ADP-ribose (ADPR)
sirtuin (SIRT)
Review
Poly(ADP-ribose) Polymerase Inhibitors
poly ADP-ribose polymerase (PARP)
medicine.disease_cause
Catalysis
ADP-ribosyl transferase (ART)
Inorganic Chemistry
ADP-Ribosylation
Transcription (biology)
Neoplasms
medicine
Animals
Humans
biochemistry
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Spectroscopy
poly ADP-ribose glycohydrolase (PARG)
Poly ADP-ribose polymerase (PARP)
chemistry.chemical_classification
Organic Chemistry
Cancer
General Medicine
medicine.disease
Computer Science Applications
Chemistry
Enzyme
chemistry
Biochemistry
ADP-ribosylation
Protein Processing, Post-Translational
Function (biology)
Oxidative stress
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....f2a67b79943eed924af1e5d6620eab66