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Improved PET/CT Respiratory Motion Compensation by Incorporating Changes in Lung Density
- Source :
- IEEE Transactions on Radiation and Plasma Medical Sciences. 4:594-602
- Publication Year :
- 2020
- Publisher :
- Institute of Electrical and Electronics Engineers (IEEE), 2020.
-
Abstract
- Positron emission tomography/computed tomography (PET/CT) lung imaging is highly sensitive to motion. Although several techniques exist to diminish motion artifacts, a few accounts for both tissue displacement and changes in density due to the compression and dilation of the lungs, which cause quantification errors. This article presents an experimental framework for joint activity image reconstruction and motion estimation in PET/CT, where the PET image and the motion are directly estimated from the raw data. Direct motion estimation methods for motion-compensated PET/CT are preferable as they require a single attenuation map only and result in optimal signal-to-noise ratio (SNR). Previous implementations, however, failed to address changes in density during respiration. We propose to account for such changes using the Jacobian determinant of the deformation fields. In a feasibility study, we demonstrate on a modified extended cardiac-torso (XCAT) phantom with breathing motion—where the lung density and activity vary—that our approach achieved better quantification in the lungs than conventional PET/CT joint activity image reconstruction and motion estimation that does not account for density changes. The proposed method resulted in lower bias and variance in the activity images, reduced mean relative activity error in the lung at the reference gate (−4.84% to −3.22%) and more realistic Jacobian determinant values.
- Subjects :
- PET/CT
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Respiratory motion compensation
Physics::Medical Physics
010103 numerical & computational mathematics
Iterative reconstruction
01 natural sciences
Imaging phantom
lung
030218 nuclear medicine & medical imaging
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Motion estimation
medicine
Radiology, Nuclear Medicine and imaging
0101 mathematics
Instrumentation
[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
[SDV.IB] Life Sciences [q-bio]/Bioengineering
Physics
density
PET-CT
medicine.diagnostic_test
Attenuation
Atomic and Molecular Physics, and Optics
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging
Positron emission tomography
Jacobian matrix and determinant
symbols
Dilation (morphology)
Index Terms-PET/CT
[SDV.IB]Life Sciences [q-bio]/Bioengineering
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Biomedical engineering
Subjects
Details
- ISSN :
- 24697303 and 24697311
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- IEEE Transactions on Radiation and Plasma Medical Sciences
- Accession number :
- edsair.doi.dedup.....f2d9952fcbd1cc1cb7244e64fcdab9a9