Back to Search
Start Over
Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease
- Source :
- Pharmaceutics, Pharmaceutics, Vol 13, Iss 1644, p 1644 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease. The pathogenesis of IBD is still unclear, which may involve environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes (30–150 nm) are found in various body fluids, including blood, saliva, urine, and cerebrospinal fluid. Exosomes mediate intercellular communication and regulate cell biological activity by carrying non-coding RNAs, proteins, and lipids. There is evidence that exosomes are involved in the pathogenesis of IBD. In view of the important roles of exosomes in the pathogenesis of IBD, this work systematically reviews the latest research progress of exosomes in IBD, especially the roles of exosomes as non-coding RNA delivery systems in the pathogenesis of IBD, including a disordered immune response, barrier function, and intestinal microbiota. The review will help to clarify the pathogenesis of IBD and explore new diagnostic markers and therapeutic targets for patients with IBD.
- Subjects :
- chronic relapsing inflammatory disease
business.industry
Cell
non-coding RNA
Pharmaceutical Science
Disease
Review
delivery system
Non-coding RNA
medicine.disease
Exosome
Inflammatory bowel disease
digestive system
Microvesicles
digestive system diseases
RS1-441
Pathogenesis
Pharmacy and materia medica
medicine.anatomical_structure
Immune system
inflammatory bowel disease
Immunology
Medicine
exosome
business
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 13
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....f2dcbc7005a9580f641063ce0207902a