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Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1
- Source :
- PLoS Genetics, PLoS Genetics, 10 (6), PLoS Genetics, Vol 10, Iss 6, p e1004439 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science, 2014.
-
Abstract
- Recombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation on a large-scale empirical fitness landscape in HIV-1 based on in vitro fitness measurements. Our results indicate that recombination substantially increases the rate of adaptation under a wide range of parameter values for population size, mutation rate and recombination rate. The accelerating effect of recombination is stronger for intermediate mutation rates but increases in a monotonic way with the recombination rates and population sizes that we examined. We also found that both fitness effects of individual mutations and epistatic fitness interactions cause recombination to accelerate adaptation. The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I.<br />PLoS Genetics, 10 (6)<br />ISSN:1553-7390<br />ISSN:1553-7404
- Subjects :
- Evolutionary Genetics
2716 Genetics (clinical)
Evolutionary Processes
lcsh:QH426-470
610 Medicine & health
10234 Clinic for Infectious Diseases
1311 Genetics
Mutation Rate
Evolutionary Adaptation
1312 Molecular Biology
Natural Selection
Genetics
1306 Cancer Research
Computer Simulation
Selection, Genetic
Recombination, Genetic
Evolutionary Biology
Models, Genetic
Genetic Drift
Biology and Life Sciences
Adaptation, Physiological
Biological Evolution
lcsh:Genetics
1105 Ecology, Evolution, Behavior and Systematics
Genetics, Population
Mutation
HIV-1
Genetic Fitness
Population Genetics
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15537390 and 15537404
- Database :
- OpenAIRE
- Journal :
- PLoS Genetics, PLoS Genetics, 10 (6), PLoS Genetics, Vol 10, Iss 6, p e1004439 (2014)
- Accession number :
- edsair.doi.dedup.....f30d2f833a69778b6c0e973c019b2395