Back to Search
Start Over
Oral administration of modified live canine parvovirus type 2b induces systemic immune response
- Source :
- Vaccine. 38:115-118
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Different strategies have been proposed to overcome maternally derived antibody (MDA) interference with canine parvovirus type 2 (CPV-2) immunisation, including intranasal vaccination, which presents some practical limitations. In the present study, the results of the oral administration of a commercial CPV-2b modified live virus (MLV) vaccine in pups with MDA are reported. The CPV-2b vaccine was orally administered to 14 6-week-old pups with a bait. Blood samples and rectal swabs were collected at different days post-vaccination (dpv) to determine CPV-2 antibody titres and DNA loads. Thirteen pups were positive to serological and virological tests after the first vaccination and one pup became positive after the second vaccine administration. The findings of this study suggest that systemic immunity against CPV-2 may be achieved by the use of an MLV CPV-2b vaccine administered orally even in the presence of MDA titres that usually interfere with vaccination.
- Subjects :
- Male
Parvovirus, Canine
animal diseases
viruses
030231 tropical medicine
Administration, Oral
Serology
Parvoviridae Infections
03 medical and health sciences
Dogs
0302 clinical medicine
Vaccine administration
Immune system
Oral administration
Animals
Medicine
Dog Diseases
030212 general & internal medicine
General Veterinary
General Immunology and Microbiology
biology
business.industry
Vaccination
Public Health, Environmental and Occupational Health
Canine parvovirus
Viral Vaccines
biology.organism_classification
Infectious Diseases
Immunology
biology.protein
Molecular Medicine
Female
Nasal administration
Antibody
business
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....f30d753135a3645233018f3bea353f77